Search results for "structural similarity"
showing 7 items of 7 documents
Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties.
2016
Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the Adverse Outcome Pathway Knowledge Base, support the development of these methods. The aim of the project presented in this publication was to develop substance categories for a read-across with complex endpoints of toxicity based on existing databases. The basic conceptual approach was to combine str…
Influence of Mitoxantrone on the Syntheses of Dna and Proteins of Mouse Tissues
1991
In view of the structural similarity of mitoxantrone to anthracyclines and its ability to intercalate into DNA, we studied its influence on the synthetic processes of DNA and proteins in CD-1 mice tissues. By studying at the DNA level the impairment of 2H-thymidine incorporation and its return to normal, it was found that bone marrow and spleen showed similar behavior, i.e., a rapid return to normal, which occurred before bone marrow cell number and spleen weight returned to basal values. At the cardiac level, the incorporation values of precursors into DNA, reduced by treatment with mitoxantrone, came back very slowly to the control ones. Hepatic DNA showed a lower sensitivity to mitoxant…
XML document-grammar comparison: related problems and applications
2011
10.2478/s13537-011-0005-1; International audience; XML document comparison is becoming an ever more popular research issue due to the increasingly abundant use of XML. Likewise, a growing interest fosters the development of XML grammar matching and comparison, due to the proliferation of heterogeneous XML data sources, particularly on the Web. Nonetheless, the process of comparing XML documents with XML grammars, i.e., XML document and grammar similarity evaluation, has not yet received the attention it deserves. In this paper, we provide an overview on existing research related to XML document/grammar comparison, presenting the background and discussing the various techniques related to th…
Construction of Chimeric Dual-Chain Avidin by Tandem Fusion of the Related Avidins
2011
BackgroundAvidin is a chicken egg-white protein with high affinity to vitamin H, also known as D-biotin. Many applications in life science research are based on this strong interaction. Avidin is a homotetrameric protein, which promotes its modification to symmetrical entities. Dual-chain avidin, a genetically engineered avidin form, has two circularly permuted chicken avidin monomers that are tandem-fused into one polypeptide chain. This form of avidin enables independent modification of the two domains, including the two biotin-binding pockets; however, decreased yields in protein production, compared to wt avidin, and complicated genetic manipulation of two highly similar DNA sequences i…
Genetic Normalized Convolution
2011
Normalized convolution techniques operate on very few samples of a given digital signal and add missing information, trough spatial interpolation. From a practical viewpoint, they make use of data really available and approximate the assumed values of the missing information. The quality of the final result is generally better than that obtained by traditional filling methods as, for example, bilinear or bicubic interpolations. Usually, the position of the samples is assumed to be random and due to transmission errors of the signal. Vice versa, we want to apply normalized convolution to compress data. In this case, we need to arrange a higher density of samples in proximity of zones which c…
Efectos de la similitud superficial y estructural sobre la transferencia a partir de análogos en problemas de alta y baja familiaridad : primeros res…
2013
Se desarrollan dos estudios exploratorios para analizar el éxito en la transferencia en resolución de problemas a partir de análogos. Las diferentes analogías entre problemas «ejemplo» y «propuestos » se suponen construidas a partir de dos variables: la superficie y la estructura. Los resultados muestran que cuando los contextos de los problemas son familiares para los estudiantes, las analogías superficiales pueden ocultar las diferencias estructurales. Sin embargo, cuando los contextos de los problemas son no familiares para los estudiantes, el único efecto significativo procede de la igualdad/diferencia estructural. El efecto global de la familiaridad de los problemas es una reducción si…
Improving structural similarity based virtual screening using background knowledge
2013
Background Virtual screening in the form of similarity rankings is often applied in the early drug discovery process to rank and prioritize compounds from a database. This similarity ranking can be achieved with structural similarity measures. However, their general nature can lead to insufficient performance in some application cases. In this paper, we provide a link between ranking-based virtual screening and fragment-based data mining methods. The inclusion of binding-relevant background knowledge into a structural similarity measure improves the quality of the similarity rankings. This background knowledge in the form of binding relevant substructures can either be derived by hand selec…